Diabetes Therapy
Chimeric rice seeds stimulate beta-cell insulin secretion
Published in Gene Therapy Weekly, May 5th, 2005
According to recent research from Japan, "glucagon-like peptide-1 (7-36) amide (GLP-1) is the most potent physiological insulinotropic hormone in humans. We produced large amounts of a GLP-1 analogue, [Ser-8, Gln-26 Asp-34]-GLP-1, which is resistant to trypsin-digestion, as part of a chimeric rice seed storage protein, a 26 kDa globulin, in genetically modified rice seeds."
"Junction sites between GLP-1 analogue and globulin were replaced by tryptic cleavage sites," wrote K. Sugita and colleagues, National Institute of Agrobiological Sciences.
"The highest level of GLP-1...
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Source: Gene Therapy Weekly (2005-05-05)
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