Published in Gene Therapy Weekly, May 5th, 2005
"A variety of clinical disorders result from mutations in mitochondrial tRNA genes, leading to translational defects. We show here that a protein complex from the kinetoplastid protozoon Leishmania induces specific, ATP-dependent import of human cytoplasmic tRNA1 Lys into human mitochondria in vitro," wrote B. Mahata and colleagues, Indian Institute of Chemical Biology.
"The imported tRNA undergoes efficient aminoacylation within the organelle and supports...
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