Gastric Cancer

Pteris semipinnata L. induced cell death in gastric cancer cells

Published in Gene Therapy Weekly, May 12th, 2005

Scientists suggested that Pteris semipinnata L. might induce cell death in gastric cancer cells.

A study from the People's Republic of China "demonstrated that Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) had stronger cytotoxicity against MKN-45, a gastric cancer cell line bearing wild-type p53 than MKN-28, another gastric cancer cell line containing missense mutation in p53."

"The rapid increase of ROS level was involved in the mechanism of cytotoxicity. Classical features of apoptosis induced by 5F were observed in MKN-45 cells only or more significant in MKN-45 cells than MKN-28 cells. Translocation of Bax from cytosol to...

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Source: Gene Therapy Weekly (2005-05-12)

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