Pheochromocytomas

Frequent promoter methylation of tumor-related genes made in pheochromocytomas

Published in Gene Therapy Weekly, May 12th, 2005

Researchers found frequent promoter methylation of tumor-related genes in sporadic and Men2-associated pheochromocytomas.

"Hypermethylation of CpG island promoters is associated with transcriptional inactivation of tumor suppressor genes in neoplasia. Inactivation of p16 and Pten was related to the development of pheochromocytomas," scientists in Germany reported.

"In this report, we investigated the methylation status of the p16(INK4a) cell cycle inhibitor gene and other prominent tumor-related genes (PTEN, RASSF1 A, CDH1, MSH2, MLH1, VHL, and TIMP3) in sporadic and multiple endocrine neoplasia type 2 (MEN2) pheochromocytomas by methylation-specific...

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Source: Gene Therapy Weekly (2005-05-12)

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