Tumor Suppression

Rb tumor suppressor in stress responses and hematopoietic homeostasis analyzed

Published in Gene Therapy Weekly, May 12th, 2005

Investigators analyzed the Rb tumor suppressor and its role in stress responses and hematopoietic homeostasis.

"The Rb tumor suppressor pathway is functionally inactivated in most human cancers. In human blood cancers, loss of Rb expression has been widely reported in both acute myeloblastic and acute lymphoblastic leukemias, cyclin D1 amplification is common in mantle cell lymphoma, and silencing of the p16/INK4a tumor suppressor gene occurs frequently in AML and various types of lymphoma," researchers in the United States reported.

"Silencing of p16/INK4A expression is frequently caused by hyper-methylation of CpG islands in its promoter but may...

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Source: Gene Therapy Weekly (2005-05-12)

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