Gene Therapy Weekly

Bone Cancer - Liposome complexes containing endostatin abate osteosarcoma metastasis

Gastroenterology - Carboxylesterase-2 gene therapy sensitizes colon cancer cells to chemotherapy

Oncology - 4T1 tumor cells determine the true fate of cancer gene therapy

Stroke - Midkine gene transfer protects brain cells against focal ischemia

Virology - Inactivated adenoviruses in microbead conjugates transfect targeted cells

Acute Lymphoblastic Leukemia - RAS mutation associated with hyperdiploidy/parental characteristics in ALL

Acute Lymphocytic Leukemia - Radiation-related ALL via pre-existing clonally expanded preleukemic cells

Acute Myeloid Leukemia - CEBP alpha gene mutations occur in 6% of childhood acute myeloid leukemia

Acute Myeloid Leukemia - Pericentric chromosome 8 inversion associated with 5'RUNX1/3'CBFA2T1 gene in AML

Alzheimer - Cognitive decline slowed by new therapy

Alzheimer Disease - Alzheimer disease pathology analyzed, characteristic features elucidated

Atherosclerosis - Researchers' data advance atherosclerosis research

Biomedical Engineering - Carbon nanotubes can transport plasmid DNA to cells

Biomedical Engineering - Thiocholesterol-based lipids allow tailored assembly of nanosize gene vectors

Breast Cancer - Multi-exonic BRCA1 deletion identified through single nucleotide polymorphism

Business Update - siARRAY RTF siRNA Libraries launched

Cancer Genetics - BARD1 implicated as potential tumor suppressor

Cancer Immunotherapy - Coexpressed ligands stimulate anti-leukemia cell immunity

Cancer Immunotherapy - Plasmid DNA and neutralized cytokine induce antitumor immunity

Cancer Research - Role for RaIGDS established

Cancer Therapy - Adenovirus bearing a mda-7 construct initiates cancer cell apoptosis

Cancer Therapy - Examination of CYP2D6 and CYP1A1 mutations shed light on malignancies in Turkey

Cancer Therapy - FOXO4 regulation used as therapeutic treatment in HER2-overexpressing cancers

Cancer Therapy - Local cytokine gene delivery augments paclitaxel in breast cancer models

Cancer Therapy - RNA interference stops breast cancer cell proliferation and invasiveness

Cardiac Research - Overexpressed oxygen-regulated protein minimizes cardiac injury

Cardiology - Findings advance knowledge in cardiology research

Cheek Cancer - Betel quid chewing linked to cheek cancer

Chronic Myelogenous Leukemia - P210(BCR/ABL) suppresses cell adhesion/motility gene expression in CML

Chronic Myeloid Leukemia - Telomerase activity may not be elevated on a cell-to-cell basis in CML

Collaborations - Collaboration to develop regulated cell therapy treatments for bone restoration

Colorectal Cancer - DCC and p27(Kip1) do not predict survival in colorectal cancer patients

Diagnostics - Company announces promising study results on Gen-Probe's prototype PCA3 assay

Disease Associations -  Shigella flexneri MxiE studied, nature of production defined

Endocrinology - Researchers' work adds to endocrinology body of knowledge

Enzymology - Phi C31 integrase-mediated gene delivery corrects tyrosinemia in murine models

Enzymology - hTERT inhibition controls laryngeal squamous cell carcinoma growth

Erectile Dysfunction - Vasoactive intestinal polypeptide improves erectile response in diabetic rats

Gastric Cancer - p16 hypermethylation detected using seminested methylation-specific PCR

Gene Expression - HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulated gene expression

Gene Research - Evolved ligase ribozyme accelerates reaction times at a variety of pH values

Gene Research - FRET-FCS evaluates the stability of oligonucleotide drugs after their delivery

Gene Research - Nucleolar localization is a prerequisite for tRNA gene-mediated silencing

Gene Silencing - Lentiviral vectors encoding short hairpin RNA stop primary effusion lymphomas

Gene Transfer - Acid-labile linkages reduce the toxicity of polyethylenimine gene carriers

Gene Transfer - Cell type and culture conditions modify the efficacy of lentiviral transduction

Gene Transfer - Hydrodynamic forces govern the trafficking of lipoplex gene vectors

Gene Transfer - Importin-beta DNA conjugates show high levels of nuclear localization