Alzheimer

Cognitive decline slowed by new therapy

Published in Gene Therapy Weekly, May 19th, 2005

PET scans and cognitive tests have suggested that Alzheimer disease patients with genetically modified tissue inserted directly into their brains show a reduction in the rate of cognitive decline and increased metabolic activity in the brain, according to a study.

PET scans demonstrated an increase in the brain's use of glucose, an indication of increased brain activity, while mental-status tests showed the patients' rate of cognitive decline was reduced by 36%-51%. In addition, researchers examined the brain tissue of a study participant who had died and found robust growth of extensions from the dying cholinergic cells near the site of growth factor gene delivery....

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Source: Gene Therapy Weekly (2005-05-19)

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