Published in Gene Therapy Weekly, May 19th, 2005
"Overexpression of RhoA or RhoC in breast cancer indicates a poor prognosis, due to increased tumor cell proliferation and invasion and tumor-dependent angiogenesis. Until now, the strategy of blockage of the Rho-signaling pathway has used either GGTI or HMG-CoA reductase inhibitors, but they are not specific to RhoA or RhoC inhibition. In this study, a new approach with anti-RhoA and anti-RhoC siRNAs was used to inhibit specifically RhoA or RhoC synthesis," scientists in France report.
"Two transfections of either RhoA or RhoC siRNA (8.5 nM) into MDA-MB-231 human breast cancer...
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