Acute Lymphoblastic Leukemia

RAS mutation associated with hyperdiploidy/parental characteristics in ALL

Published in Gene Therapy Weekly, May 19th, 2005

RAS gene mutation is associated with hyperdiploidy/parental characteristics in pediatric acute lymphoblastic leukemia.

According to a recently published study from the United States, "We explored the relationship of RAS gene mutations with epidemiologic and cytogenetic factors in a case series of children with leukemia.

"Diagnostic bone marrow samples from 191 incident leukemia cases from the Northern California Childhood Leukemia Study were typed for NRAS and KRAS codon 12 and 13 mutations."

"A total of 38 cases (20%) harbored RAS mutations," scientists in the United States report. Among the 142 B-cell acute lymphoblastic...

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Source: Gene Therapy Weekly (2005-05-19)

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