Signal Transduction

Embryonic signal transduction analyzed, role of protein homolog revealed

Published in Gene Therapy Weekly, May 19th, 2005

According to recent research from Singapore, a homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo.

"Orthologues of nearly all of the core components of the Hedgehog signalling pathway, defined originally through genetic analysis in Drosophila, have now been discovered in vertebrates and shown to have highly conserved functions.

"The one striking exception to this rule is the kinesin-like protein Costal2, which plays a central role in controlling the activity of the zinc-finger-containing transcriptional regulator, Cubitus interruptus that modulates all Hedgehog-dependent target...

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Source: Gene Therapy Weekly (2005-05-19)

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