Gene Therapy Weekly

Gene Transfer - Amphiphilic block copolymers disseminate plasmid DNA with minimal harm

Gene Transfer - New data illuminates research in gene transfer

Gene Transfer - Supramolecular gene delivery vectors excel at transfection

Head & Neck Cancer - Cathepsin B RNA inhibitors may prevent oral cancer invasion

Heat Shock Protein - Heat shock protein 70 examined, role in clonogenicity of leukemic cells revealed

Hematology - Researchers detail new studies and findings in the area of hematology

Immunology - Research in immunology provides new insights

Inhibitors - Histone deacetylase inhibitors affected DNA methylation

Leukemia - Gene mutations in TRAIL receptors were absent in chronic myelogenous leukemia

Lipid Research - Apolipoprotein A-I deletions corrupt lipid metabolism in study models

Liver Cancer - Genes involved in fenretinide-induced apoptosis identified

Liver Fibrosis - Triplex-forming oligonucleotide may cure chronic liver disease

Lung Cancer - ACS cited as mechanism responsible for tumor recurrence and progression

Lymphoid Development - Frizzled 9 knock-out mice have abnormal B-cell development

Melanoma - Melanoma cells express elevated levels of phosphorylated histone H2AX foci

Metabolism - Patients with metabolic syndrome could benefit from RNA interference

Muscular Dystrophy - Findings advance knowledge in muscular dystrophy research

Myocardial Infarction - Human eNOS gene delivery renders aid to injured hearts

Neuroblastoma - Gene profiling of high-risk neuroblastoma conducted

Neuroscience - Alpha 4 integrin blockade staunches experimental autoimmune encephalomyelitis

Oncology - Antisense oligonucleotide-mediated hTERT inhibition hinders prostate cancer

Oncology - Maspin promotion limits tumor metastasis

Oncology - Reports add new data to oncology research

Orthopedics - Gene therapy holds promise for generating new bone growth

Parkinson Disease - Phase 1 trial of gene therapy for Parkinson disease presented at AANS meeting

Patents - Company wins patent related to detection of mRNAs

Prostate Cancer - Activation of p53/p21(Waf1/Cip1) pathway inhibited cell proliferation

Proteomics - Targeted aquaporin-1 gene disruption impairs cell migration and angiogenesis

Pulmonary Medicine - Anti-interleukin 8 therapy arrests inflammatory signals in airway cells

Pulmonary Medicine - Decoy oligodeoxynucleotides protect against septic acute lung injury in mice

Squamous Cancer - T-cadherin negatively regulates cutaneous squamous carcinoma proliferation

Stem Cell Disorders - Acquired PTPN11 mutations rarely occur in myelodysplastic syndromes and CMLL

T-Cell Large Granular Lymphocyte Leukemia - Epitope defined for HTLV env seroreactivity observed in LGL leukemia

Tamoxifen - Methylation rate of the ER beta gene and tamoxifen resistance inversely related

Tick-Borne Fever - Cellular genes identified in response to A. phagocytophilum infection

Type 1 Diabetes - Insulin gene therapy may overcome the drawbacks of islet transplantation

Vector Development - Gal-alpha-cyclodextrin conjugates have improved gene transfer capabilities

Vector Development - Non-viral vectors offer a safe approach to long-term gene expression

Vector Development - Researchers detail new studies and findings in the area of vector development

Virology - Helper-dependent adenoviral vector eradicates hyperbilirubinemia

Virology - New research in the area of virology detailed

Virus Activation - K-Rta essential for lytic viral reactivation and transactivation of viral genes