Lymphoid Development
Frizzled 9 knock-out mice have abnormal B-cell development
Published in Gene Therapy Weekly, May 26th, 2005
According to a recently published report from the United States, "The binding of frizzled (Fzd) receptors by their Writ ligands results in the inhibition of beta-catenin degradation and subsequent transcription of beta-catenin/LEF-inducible genes.
"The beta-catenin pathway is known to be involved in development, tumorigenesis, and stem cell self-renewal. In humans, the FZD9 gene lies in the region of chromosome 7q11.23 deleted in the neurodevelopmental disorder, Williams-Beuren syndrome (WBS)."
"Fzd9-/- mice show no obvious features of WBS, but reveal a role for Fzd9 in...
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Source: Gene Therapy Weekly (2005-05-26)
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