Prostate Cancer

Activation of p53/p21(Waf1/Cip1) pathway inhibited cell proliferation

Published in Gene Therapy Weekly, May 26th, 2005

Activation of p53/p21(Waf1/Cip1) pathway by 5-aza-2'-deoxycytidine might inhibit cell proliferation and induce pro-apoptotic genes in human prostate cancer.

"The tumor suppressor gene p53 plays an essential role in cell proliferation and apoptosis. Due to its relevance to cancer therapy, most studies have focused on the cellular consequences of p53 activation in relation to cytotoxic drugs. 5-aza-2'-deoxycytidine (5-aza-CdR) is widely used as an anticancer drug for the treatment of leukemia and solid tumors," scientists in the United States reported.

"However, the mechanism by which 5-aza-CdR exerts its antineoplastic activity remains unclear. Here,...

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Source: Gene Therapy Weekly (2005-05-26)

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