Antileukemic
Third generation biphosphate YM529 antileukemic
Published in Gene Therapy Weekly, May 26th, 2005
Ras proteins are frequently over-expressed in leukemia and contribute to leukemogenesis. We evaluated the anti-leukemic efficacy of a new third-generation bisphosphonate, ON05920/YM529 (YM529).
"YM529 prevents the prenylation of Ras proteins and inhibited the growth of leukemic cells including a P-glycoprotein (P-gp) overexpressing cell line in a concentration- and time-dependent manner by inducing apoptosis in vitro," scientists in Japan report.
"Moreover," said H. Segawa and coauthors at Kyoto University Hospital, "YM529 synergistically augmented the...
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Source: Gene Therapy Weekly (2005-05-26)
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