Apoptosis
Bivalent single-chain antibody fragments induce apoptosis in myeloma cells
Published in Gene Therapy Weekly, May 26th, 2005
"Multiple myeloma is currently considered incurable despite the use of high-dose chemotherapy with autologous hematopoietic stem cell transplantation support. Here, we show antitumor efficacy of a novel bivalent single-chain antibody fragment (scFv) against CD47 in an in vivo myeloma model.
"We generated two types of novel scFv molecules against CD47 having apoptosis-inducing activity for leukemic cell lines: a noncovalently linked scFv dimer (diabody) and a covalently linked bivalent scFv," researchers in Japan report.
"Administration of these bivalent...
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Source: Gene Therapy Weekly (2005-05-26)
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