Soft Tissue Sarcoma
RASSF1A inactivation is a common event in soft tissue sarcomas
Published in Gene Therapy Weekly, June 2nd, 2005
According to a study from Germany, "Aberrant methylation is a main mechanism of tumor suppressor gene inactivation in carcinogenesis.
"In this study, the methylation status of RASSF1A, p16, MLH1, MSH2 and ERalpha was investigated in 84 primary soft tissue sarcomas (STSs), including 22 liposarcomas, 18 malignant fibrous histiocytomas (MFHs), 18 leiomyosarcomas, 6 rhabdomyosarcomas, 6 neurogenic sarcomas and several other sarcoma entities."
"RASSF1A hypermethylation was detected in 17 of 84 (20%) STSs; however, methylation was more frequent in leiomyosarcomas (39%)...
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Source: Gene Therapy Weekly (2005-06-02)
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