Gastroenterology
Antisense trefoil factor family-3 sensitizes gastric cancer to adryamicin
Published in Gene Therapy Weekly, June 9th, 2005
According to a study from the Peoples Republic of China, "intestinal trefoil factor (ITF), which is normally absent in gastric mucosa, is over-expressed in gastric cancer. However, the functional significance of ITF in gastric cancer is unknown."
"We examined the effects of blocking ITF expression on the growth of gastric cancer cells and their responses to chemotherapeutic agents. Antisense ITF cDNA was cloned into mammalian expression vector pcDNA3 and was transfected into an ITF-expressing gastric cancer cell line SNU-1. We assessed the doubling time and anchorage dependent...
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Source: Gene Therapy Weekly (2005-06-09)
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