Stem Cell Research
Peroxisome proliferator-activated receptors are targets for drug development
Published in Gene Therapy Weekly, June 9th, 2005
"Mast cells are derived from stem cells in bone marrow and their proliferation and differentiation are regulated by stimulation of stem cell factor derived from fibroblasts and/or IL-3 from T lymphocytes.
"The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and ligand-activated transcription factors. It has been reported that PPARgamma is expressed in mast cells, but its roles remain uncertain," investigators in Japan wrote.
"Since mast cells produce and release prostaglandin D-2, which is...
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Source: Gene Therapy Weekly (2005-06-09)
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