Vaccine Vector
Adenovirus cross-reactivity in delayed-type hypersensitivity examined
Published in Gene Therapy Weekly, June 9th, 2005
According to a study from Hungary, "The aim of this study was to determine the antigen responsible for the induction of delayed-type hypersensitivity (DTH) by human adenoviruses (Ads). The estimation of DTH was based on measurement of the extent of swelling of the hind footpads of mice. CsCl density gradient-purified human Ad serotype 6 (Ad6) induced DTH in a dose-dependent manner. In Ad6-sensitized mice, DTH could be elicited by serotypes belonging to the same species of human Ads (types 1 and 5) and by a serotype (type 3) belonging to...
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Source: Gene Therapy Weekly (2005-06-09)
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