Brain Cancer
Fos-related antigen 1 enables glioma to maintain a malignant phenotype
Published in Gene Therapy Weekly, June 16th, 2005
"Malignant gliomas, and high-grade gliomas (HGG) in particular, are non metastasizing but locally infiltrating, hypervascularized brain tumors of poor prognosis. We found previously that a c-fos-inducible vascular endothelial growth factor D is ubiquitously up-regulated in HGG grade IV, glioblastoma multiforme, and that glioblastoma multiforme overexpress Fos-related antigen 1 (Fra-1) rather than the c-Fos," researchers in the United States report.
"We have thus become interested in the role Fra-1 may play in malignant glioma progression/maintenance, because Fra-1 has the...
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Source: Gene Therapy Weekly (2005-06-16)
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