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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . June 23rd, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Cancer Therapy - NRAS gene suppression initiates melanoma cell apoptosis

Cancer Therapy - PTEN gene therapy treats prostate cancer alone and with other agents

Cardiology - Sorcin stimulation may benefit patients with heart failure

Oncology - Antiangiogenic immunotherapy targets signals that fortify cancer growth

Vector Delivery - Aurintricarboxylic acid reinforces intratumoral non-viral gene transfer

Acute Myeloid Leukemia - Wnt/beta-catenin pathway involved in acute myeloid leukemia pathogenesis

Amoxicillin - Amoxicillin interaction with DNA in human lymphocytes studied

Apoptosis - Vectors encoding apoptin or E4orf4 produce temporary tumor killing

Arthritis - Kallistatin gene transfer prevents arthritic disease in rodent models

Awards - $250,000 prize in developmental biology awarded to pioneers in genetic research

Biological Therapy - Understanding tumor suppressive mechanisms of SCs may lead to cancer therapies

Cardiology - Researchers detail new studies and findings in the area of cardiology

Biomedical Engineering - Launch of software systems for detection of biomolecular interactions announced

Biomedical Engineering - Scientists find gene that expresses differently in left, right cerebral cortex

Bone Cancer - Osteosarcoma cells respond differentially to tumor suppressor gene therapy

Bone Cancer - Recent findings in bone cancer provide new insights

Breast Cancer - Diagnostics company updates NMP66 protein program for breast cancer detection

Breast Cancer - Link between ICAM1 gene and breast cancer metastasis reported in published study

Business & Finance - Genetics company reports Q1 net loss of $4,280,000

Business Update - Biotechnology company receives NASDAQ notice of noncompliance, submits plan

Business Update - New DNA labeling system launched for aCGH

Cancer Metastasis - Platelet factor 4 gene transfection prevents tumor-associated vessel formation

Cancer Therapy - Recent findings illuminate research in cancer therapy

Cardiology - Midkine repression prevents balloon injury-induced neointima formation

Cardiology - Mifepristone-controlled transgenes model cardiac phenotypes in mice

Cardiology - NCX1 depletion does not prevent cardiomyocyte contraction

Cardiology - Reports describe recent advances in cardiology research

Cervical Cancer - ORI-1001 antisense oligonucleotide stifles human papillomavirus replication

Chronic Myelogenous Leukemia - CML progenitor cells identified with hemangioblastic characteristics

Clinical Trials - Company reports early results in clinical trial of drug combination for NSCLC

Colon Cancer - Blockade of Wnt-1 signaling induced apoptosis in human colorectal cancer cells

Colorectal Cancer - Interleukin-4 gene transduction drives antitumor efforts in mice

DNA Vaccine - Nuclear transfer of plasmid DNA condensed with protamine evaluated

DNA Vaccine - Penetratin enhances polymethacrylate-mediated gene delivery

Dermatology - Mutant BRAF boosts melanoma cell dedifferentiation

Dermatology - Osteopontin encourages melanoma growth and invasion

Diabetic Cardiomyopathy - VEGF depletion diminishes cardiac function in hearts injured by diabetes

Drug Delivery - Studies add new findings to drug delivery body of knowledge

Finance - Biotech company approved for listing on the American Stock Exchange

Gastroenterology - Findings advance knowledge in gastroenterology research

Gene Silencing - Inducible transcription systems based on the H1 promoter push RNA interference

Gene Therapy - Strategies to enhance tumor visibility improve cancer immunotherapy

Gene Transfer - Researchers' work adds to gene transfer body of knowledge

Growth Factor - Growth differentiation factor-9 studied, expression and function clarified

Heart Transplant - Glycosyltransferase genes induced histoblood group A antigen expression

Hematology - New data illuminates research in hematology

Information Technology - Genomics institute to use grid interconnect system as part of HP supercomputer

Mergers & Acquisitions - Company to acquire Targeted Molecules, secures bridge financing facility

Mergers & Acquisitions - Investments company completes Gen ID acquisition, appoints new directors

Neurology - Scorpion neurotoxin cloned, potassium channel-blocking activity reported

Neuroscience - Research add new data to neuroscience body of knowledge

Oncology - Chemokine CXCL14 is a potent dendritic cell chemoattractant

Orthopedics - Reports add new data to orthopedics research

Ovarian Cancer - Cyclooxygenase-1 targeted for prevention and treatment of ovarian cancer

Ovarian Cancer - Reports describe recent advances in ovarian cancer research

Pancreatic Beta Cells - Efficient restricted gene expression in beta cells reported

Parkinson Disease - Delayed gene therapy is efficacious in rat model of Parkinson disease

Peripheral Vascular Disease - Angiogenesis declines without sustained gene expression after VEGF transfer

Personnel - Steven J. Mento appointed to board of directors by DNA-focused research company

Pulmonary Medicine - Uteroglobin constructs block COX-2 expression in lung cancer cells

Renal Cancer - Antisense blockade of FGF-2 restrains renal cancer endothelial cell migration

Renal Cancer - Bcl-2 inhibition improves the effects of renal cell carcinoma chemotherapy

Renal Cell Cancer - MN/carbonic anhydrase IX promoter restricts renal cell carcinoma growth

Respiratory Medicine - Studies add new findings to respiratory medicine body of knowledge

Retinopathy - Angiostatin gene delivery stops preretinal neovascularization in rodent models

Rheumatology - Small interfering RNA halts joint inflammation in murine arthritis models

Vaccine Vector - Best vector systems for gene transduction into dendritic cells studied

Vaccine Vector - Lentivirus vector induces megakaryocyte-specific gene expression

Vaccine Vector - Single regulated lentiviral vectors compared to constitutive promoter

Vaccine Vector - Vector developed using bacterial artificial chromosome cloning

Vaccine Vector - Vectors and delivery systems in gene therapy reviewed

Vaccines Development - New research in the area of vaccines development detailed

Vector Development - Research in vector development provides new insights

Virology - MicroRNA confronts viruses in human cells

Virology - Pseudotyped retroviral vectors kill cancer and augment suicide gene therapy

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