Pancreatic Beta Cells

Efficient restricted gene expression in beta cells reported

Published in Gene Therapy Weekly, June 23rd, 2005

Lentivirus-mediated gene transfer into pancreatic stem/progenitor cells leads to efficient restricted gene expression in beta cells.

According to a study from France, "Gene transfer into pancreatic beta cells, which produce and secrete insulin, is a promising strategy to protect such cells against autoimmune destruction and also to generate beta cells in mass, thereby providing a novel therapeutic approach to treat diabetic patients. Until recently, exogenous DNA has been directly transferred into mature beta cells with various levels of success. We investigated whether exogenous DNA could be stably transferred into pancreatic stem/progenitor cells, which would...

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Source: Gene Therapy Weekly (2005-06-23)

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