Rheumatology

Small interfering RNA halts joint inflammation in murine arthritis models

Published in Gene Therapy Weekly, June 23rd, 2005

Small interfering RNA halts joint inflammation in murine arthritis models.

According to recent research published in the journal Arthritis and Rheumatism, "RNA interference is a process in which genes can be silenced sequence-specifically. In mammals, RNA interference can be invoked by introduction of small (19-21-nucleotide) double-stranded RNA molecules known as small interfering RNA (siRNA) into cells."

"Thereby, siRNA offers promise as a novel therapeutic modality. However, siRNA is a relatively large, highly charged molecule and does not readily enter cells. This study was undertaken to investigate the use of electroporation for in vivo...

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Source: Gene Therapy Weekly (2005-06-23)

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