Vaccine Vector

Lentivirus vector induces megakaryocyte-specific gene expression

Published in Gene Therapy Weekly, June 23rd, 2005

HIV-1-derived self-inactivating lentivirus vector induces megakaryocyte lineage-specific gene expression.

According to a study from Japan, "Pluripotent, self-renewing, hematopoietic stem cells are considered good targets for gene modification to treat a wide variety of disorders. However, as many genes are expressed in a stage-specific manner during the course of hematopoietic development, it is necessary to establish a lineage-specific gene expression system to ensure the proper expression of transduced genes in hematopoietic stem cells."

"In this study, we constructed a VSV-G-pseudotyped, human immunodeficiency virus type I-based, self-inactivating...

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Source: Gene Therapy Weekly (2005-06-23)

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