Apoptosis
Vectors encoding apoptin or E4orf4 produce temporary tumor killing
Published in Gene Therapy Weekly, June 23rd, 2005
According to recent research from Poland, "the aim of our study was to investigate whether apoptin and e4orf4 pro-apoptotic genes, transferred by means of electroporation, were suitable for gene therapy of tumors. The two genes were chosen for our study because the proteins they encode induce apoptosis in transformed cells only."
"The apoptin gene was synthesized based on a published nucleotide sequence," wrote I. Mitrus and colleagues, Marie Curie Sklodowska Memorial Cancer Center.
"MTT and TUNEL tests confirmed that both the synthesized apoptin gene and the...
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Source: Gene Therapy Weekly (2005-06-23)
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