Diagnostics

Genetic and epigenetic alterations of PTEN gene in soft tissue sarcomas studied

Published in Gene Therapy Weekly, June 30th, 2005

Researchers studied genetic and epigenetic alterations of the PTEN/MMACI (PTEN) gene in soft tissue sarcomas (STSs).

"The PTEN gene was identified as a tumor suppressor gene encoding a cytoplasmic protein that controls cellular processes," scientists in Japan reported.

"To investigate the potential role and the alteration of the PTEN gene in STSs, we searched for homozygous deletion and promoter hypermethylation in a series of 48 STSs that was composed of malignant fibrous histiocytoma, leiomyosarcoma, malignant peripheral nerve sheath tumor, including 2 cases with a mutation that we previously reported; differential polymerase chain reaction and...

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Source: Gene Therapy Weekly (2005-06-30)

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