Spinal Cord Injury
Poliovirus replicons encoding interleukin-10 encourage spinal cord recovery
Published in Gene Therapy Weekly, July 14th, 2005
"Poliovirus-based vectors (replicons) have been shown to maintain the in vitro tropism of poliovirus for motor neurons of the CNS. To determine if replicons could be effective for delivery of potentially beneficial proteins to the CNS, we have constructed and characterized a replicon encoding IL-10," researchers in the United States report.
"IL-10 was rapidly produced in tissue culture cells following in vitro infection with replicons encoding IL-10. Intrathecal inoculation of replicons encoding IL-10 into the non-injured CNS of mice transgenic for the poliovirus receptor...
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Source: Gene Therapy Weekly (2005-07-14)
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