SARS Vaccine
siRNA targeting Leader sequence of SARS-CoV inhibits virus replication
Published in Gene Therapy Weekly, July 14th, 2005
"SARS-CoV (the SARS-associated coronavirus) was reported as a novel virus member in the coronavirus family, which was the cause of severe acute respiratory syndrome. Coronavirus replication occurs through a unique mechanism employing Leader sequence in the transcripts when initiating transcription from the genome. Therefore, we cloned the Leader sequence from SARS-CoV(BJ01),which is identical to that identified from SARS-CoV(HKU-39849), and constructed specific siRNA targeting the Leader sequence," scientists in China and Canada report.
"Using EGFP and RFP reporter genes...
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Source: Gene Therapy Weekly (2005-07-14)
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