Gene Research
DNA vector-based RNA interference depletes poly(ADP-ribose) polymerase-1
Published in Gene Therapy Weekly, July 21st, 2005
"RNA-mediated interference (RNAi) is a powerful technique that is now being used in mammalian cells to specifically silence a gene. Some recent studies have used this technique to achieve variable extent of depletion of a nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1)," scientists writing in the journal Biochemical and Biophysical Research Communications report.
"These studies reported either transient silencing of PARP-1 using double-stranded RNA or stable silencing of PARP-1 with a DNA vector which was introduced by a viral delivery system," wrote R.G. Shah and...
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Source: Gene Therapy Weekly (2005-07-21)
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