Drug Delivery
Selective stabilized plasmid-lipid particles show longevity
Published in Gene Therapy Weekly, July 28th, 2005
"Stabilized plasmid lipid particles (SPLP) consist of a single copy of DNA surrounded by a lipid bilayer, the particles are small (approximatey 100 nm), stable, monodisperse and have a low surface charge. A diffusible polyethylene glycol (PEG) coating attached to a lipid anchor is critical to the SPLP's functionality," researchers in Canada report.
"The PEG-lipid exchanges out of the bilayer at a rate determined by the size of the lipid anchor. Here we show that SPLP can be prepared using a series of PEG-diacylglycerol lipids (PEG-S-DAGs). SPLP were prepared incorporating...
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Source: Gene Therapy Weekly (2005-07-28)
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