Fibrinogen
Angiopoietin-1 variant discourages neovascular proliferation
Published in Gene Therapy Weekly, July 28th, 2005
According to a study from Switzerland, "the vessel-stabilizing effect of angiopoietin-1 (Ang1)/ Tie2 receptor signaling is a potential target for pro-angiogenic therapies as well as antiangiogenic inhibition of tumor growth. We explored the endothelial and vascular specific activities of the Ang1 monomer, i.e. dissociated from its state as an oligomer."
"A truncated monomeric Ang1 variant (i.e. DeltaAng1) containing the isolated fibrinogen-like receptor-binding domain of Ang1 was created and recombinantly produced in insect cells. DeltaAng1 ligated the Tie2 receptor without triggering its...
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Source: Gene Therapy Weekly (2005-07-28)
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