Liver Cancer

Small interfering RNA focuses on hepatocellular carcinoma oncoprotein

Published in Gene Therapy Weekly, August 4th, 2005

Small interfering RNA focuses on hepatocellular carcinoma oncoprotein.

According to a study from the People's Republic of China, "RNA interference (RNAi) is a powerful tool to silence gene expression. The adenoviral vector expressing small interfering RNA (siRNA) is highly effective in mammalian cells."

"However, its potential use as a therapeutic tool to target an oncogene specifically remains to be seen. We applied the adenovirus-delivered siRNA (AdSiRNA) to inhibit a hepatocellular carcinoma (HCC) oncogene, p28GANK, in HCC cell lines and investigated its antitumor effects. The T7-RNA polymerase system was used to screen the specific target site,"...

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Source: Gene Therapy Weekly (2005-08-04)

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