Alzheimer Disease
Water-soluble amyloid-beta studied, role in Alzheimer disease revealed
Published in Gene Therapy Weekly, August 4th, 2005
"wsAbeta is present in cerebral cortex of subjects at risk of AD as well as in normal elderly subjects as a mixture of three major Abeta species: 1-42, py3-42 and py11-42. The three wsAbeta species are nondetectable in brains of young people, free of immunohistochemically detectable amyloid plaques," wrote M. Tabaton and colleagues, University of Genoa.
"In the brains of Down syndrome and APP-mutant transgenic mice, wsAbeta appears a long time before amyloid deposition, indicating that it represents the first...
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Source: Gene Therapy Weekly (2005-08-04)
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