Drug Development
Inducible suicide gene therapy harnesses the power of caspase 8
Published in Gene Therapy Weekly, August 11th, 2005
According to recent research from France, "suicide gene-therapy strategies are promising approaches in treating various diseases such as cancers, atherosclerosis, and graft-versus-host-disease. Here, we describe the development of a new effector gene based on inducing functional caspase 8, the initiator caspase in the death-receptor pathway."
"We constructed vectors encoding a constitutively active form of human caspase 8 (CC8), and demonstrated the efficient killing of a variety of cell types in transfection and lentivirus-transduction assays," explained F. Carlotti and colleagues,...
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Source: Gene Therapy Weekly (2005-08-11)
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