Hematology
TNF-alpha matures leukemia cells into antigen-presenting cells
Published in Gene Therapy Weekly, August 11th, 2005
According to a study from France, "acute myeloid leukemia (AML) cells can be differentiated into dendritic cells (DCs) using appropriate combinations of cytokines but generation of autologous antileukemic cytotoxic T cells using leukemic DCs remains difficult. Transduction by adenoviral vectors has been reported to induce efficient maturation of monocyte-derived DCs but AML cells are generally resistant to adenoviral gene transfer."
"In this study we tested the effects of adenoviral tumor necrosis factor-alpha (TNF-alpha) gene transfer on maturation of AML cells using the fiber-modified...
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Source: Gene Therapy Weekly (2005-08-11)
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