Published in Gene Therapy Weekly, August 11th, 2005
"The GR, a member of the nuclear receptor superfamily, mediates the effects of glucocorticoids. It is known that 14-3-3 family proteins interact with GR and regulate its transcriptional activity.
"They also bind to several molecules and influence many cellular events by altering their subcellular localization and/or acting as a chaperone," wrote Y.S. Kim and colleagues, Korea University.
"Recently, it has been proposed that ligand-activated degradation of GR occurs via the...
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