Vector Development
RGD fiber-mutant vectors raise the safety profile of melanoma gene therapy
Published in Gene Therapy Weekly, August 11th, 2005
According to recent research from Japan, "since RGD fiber-mutant adenovirus vector (AdRGD), which contains an av-integrin tropism, is highly efficient in gene transduction to melanoma, the AdRGD-mediated herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) system is an attractive approach for melanoma treatment. However, the intratumoral injection of AdRGD causes limited transgene expression in healthy normal tissue, due to unwanted vector spread."
"Herein, we describe our attempt to overcome this limitation related to the safety of HSVtk/GCV treatment by using...
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Source: Gene Therapy Weekly (2005-08-11)
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