microRNA polycistron is potential oncogene

"To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, noncoding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas," wrote investigators in the United States.

"Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers," reported L. He and colleagues at Cold Spring Harbor...

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