Vector Development
HIV-1-derived lentivirus vector induces megakaryocyte gene expression
Published in Gene Therapy Weekly, August 11th, 2005
According to recent research published in the journal Microbes and Infection, "Pluripotent, self-renewing, hematopoietic stem cells are considered good targets for gene modification to treat a wide variety of disorders. However, as many genes are expressed in a stage-specific manner during the course of hematopoietic development, it is necessary to establish a lineage-specific gene expression system to ensure the proper expression of transduced genes in hematopoietic stem cells."
"In this study, we constructed a VSV-G-pseudotyped, human...
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Source: Gene Therapy Weekly (2005-08-11)
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