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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . September 1st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Angiology - Decoy transcription factor prevents abdominal aortic aneurysm formation

Diabetes Therapy - Antisense oligonucleotides improve glucose control in diabetic mice

Myocardial Infarction - Hypoxia-inducible factor 1 alpha augments skeletal myoblast transplantation

Oncology - Interleukin-12 gene transfer and chemotherapy hinders murine tumors

Virology - Transposon-based systems seek insertion sites to improve viral gene delivery

Adenocarcinoma - Transformed bronchioalveolar stem cells give rise to adenocarcinoma

Adenovirus Vector - Capsid modifications enable flexible targeting of adenovirus vectors

Apoptosis - Apoptosis regulated by alternative pre-mRNA splicing

Awards - Society honors five scientists for outstanding work in blood cancer research

Awards - U.S. NIAD grant up to $4.9 million awarded to develop infection biosensor system

Bioinformatics - Web tools facilitate the design and optimization of RNAi constructs

Cancer Vaccines - Researchers detail new studies and findings in the area of cancer vaccines

Brain Cancer - New findings in the area of brain cancer described

Business & Finance - President and CEO Dr. Lawrence Olanoff granted stock option award

Cancer Therapy - CK2 blockade impedes cellular survival

Cancer Vaccines - New findings in the area of cancer vaccines described

Cardiology - Reports add new data to cardiology research

Liver Cancer - Researchers' findings advance liver cancer research

Collaborations - Companies collaborate on DNA vaccine technology

Colon Cancer - Viral vector helps interleukin-12 eliminate murine colon adenocarcinomas

DNA Research - Molecular genealogy foundation to include Singapore families in DNA database

DNA Vaccine - Beta-amino ester polymers facilitate in vivo DNA transfection

DNA Vaccine - Repressor protein immobilized for binding of plasmid DNA

Dermatology - Integrin beta signaling domain effects of deletion defined

Proteomics - New findings in the area of proteomics described

Diabetes Complications - Platelet-derived growth factor gene transfer accelerates diabetic wound healing

Diabetes Therapy - Researchers provide details of new studies and findings in the area of diabetes therapy

Drug Delivery - DMXAA may ease drug and gene delivery by increasing vascular permeability

Drug Delivery - Engineered bio-nanocapsules transport proteins to liver cells

Drug Delivery - Transdermal drug-delivery device company launches human clinical trial

Drug Development - U.S. FDA grants orphan drug status for lysosomal acid lipase product

Proteomics - New research in the area of proteomics detailed

Drug Development - U.S., Japan, Europe have legislation to spur orphan drug production, study says

Enzymology - Anti-uPAR DNAzymes staunch osteosarcoma cell invasion

Enzymology - Small interfering RNA produces gene-specific control in zebrafish embryos

Finance - DNA-focused biopharmaceutical company reports Q2 2005 financial results

Finance - Eligen technology company announces 2005 second-quarter results

Finance - Gene expression-focused biotech company transfers securities to NASDAQ SmallCap

Vector Development - Researchers report details of new studies and findings in the area of vector development

Finance - Genetics-focused biopharmaceutical company reports Q2 2005 financial results

Finance - Personalized health products developer reports Q2 2005 financial results

Finance - Protein therapeutics developer announces proposed common stock offering

Gene Regulation - A WAP-promoter fragment directs gene expression in murine mammary cells

Gene Research - Histone H3 K56 acetylation favors DNA repair

Gene Research - Specific response elements guide p63 activation of targeted genes

Gene Silencing - Short hairpin RNA triggers de novo methylation in human cells

Genetics & Genomics - University of Miami genetics center signs agreement with reagents supplier

Geriatrics - Systematic RNA interference screens nematodes for longevity genes

Glioma - TIMP-3 evokes a number of processes to staunch tumor growth

Grants - Multi-million dollar grant awarded to identify genetic signatures of pathogens

Heart Disease Therapy - Long-term cardiac gene expression achieved using coxsackieviral vector

Human Papillomavirus Vaccines - Reports describe recent advances in human papillomavirus vaccines research

Leukemia - Chronic myeloid leukemia used as model for oncology

Liver Cancer - Adeno-associated virus-mediated TRAIL gene therapy fights cancer metastasis

Liver Cancer - Reports describe recent advances in liver cancer research

Molecular Biology - "Cookbook recipes" would cure disease with nontoxic DNA delivery systems

Myeloma - Atiprimod induced apoptosis in multiple myeloma cells

Obstetrics - In utero gene delivery elucidates placental vascularity in mice

Oncogenes - MET targeted in gene therapy

Pancreatic Cancer - Phase II trial of pancreatic cancer treatment successfully completed

Patents - Gene-focused company announces patent issuance to make adeno-associated virus

Personnel - Biotech company names James Rotherham and Peter Myers to executive positions

Personnel - Cell and gene therapy company adds to scientific advisory board

Personnel - Gene-based pharma company names two directors

Personnel - Michael S. Paul promoted to president, COO by genetics-focused biotech company

Personnel - Nicole Onetto, MD, named senior VP and CMO by protein therapeutics developer

Protein Production - Baculovirus expression optimized for protein production in insect cells

Proteomics - New data illuminates research in proteomics

Receptors - Lung fibrosis analyzed, effect of mutant human epidermal receptor revealed

Renal Cancer - Studies advance knowledge in renal cancer research

Rheumatology - Studies add new findings to rheumatology body of knowledge

Schistosomiasis - Decoy therapy overwhelms parasite-related liver fibrosis

Thyroid Cancer - Value of nm23 as prognosticator of parathyroid neoplasia assessed

Transgenics - Enzyme overexpression analyzed, effect on myelin stability revealed

Urology - Findings describe new data in urology research

Vaccine Vector - Lentiviral vectors appear safe and effective for fetal gene delivery

Vaccine Vector - Transgene expression prolonged in salivary glands after transduction

Vector Development - Conserved regions of tyrosine hydroxylase promoter characterized

Vector Development - Lipid-protamine-DNA complexes deliver antisense c-myc oligonucleotides

Vector Development - Neomycin augments lipid-based oligonucleotide delivery

Vector Development - New data illuminates research in vector development

Vector Development - Targeted polyplexes enhance transfection efficiency

Virology - Recent studies add new data to virology research

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