Receptors

Lung fibrosis analyzed, effect of mutant human epidermal receptor revealed

Published in Gene Therapy Weekly, September 1st, 2005

According to recently published research from the United States, expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice.

"Neuregulin-1 (NRG-1) binding to the human epidermal growth factor receptor HER2/HER3 plays a role in pulmonary epithelial cell proliferation and recovery from injury in vitro. We hypothesized that activation of HER2/HER3 by NRG-1 would also play a role in recovery from in vivo lung injury," wrote D.E. Nethery and colleagues, University of Cleveland Hospital.

"We tested this hypothesis using bleomycin lung injury of transgenic mice incapable of signaling through HER2/HER3 due to...

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Source: Gene Therapy Weekly (2005-09-01)

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