Vaccine Vector

Transgene expression prolonged in salivary glands after transduction

Published in Gene Therapy Weekly, September 1st, 2005

Transgene expression was prolonged in murine salivary glands following non-primate lentiviral vector transduction.

"Salivary glands are an accessible organ for gene therapy, enabling expression of recombinant proteins for both exocrine and endocrine secretion. Lentivirus-based vectors have many advantages for gene therapy, including their ability to infect nondividing cells and to stably integrate into the host genome, enabling long-term transgene expression without eliciting an inflammatory immune response," researchers in Israel report.

"In the present study, murine salivary glands were inoculated with feline immunodeficiency virus (FIV)-based...

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Source: Gene Therapy Weekly (2005-09-01)

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