Beta-Amyloid

Neuroinflammation and dysfunction studied, role of human beta-amyloid defined

Published in Gene Therapy Weekly, September 8th, 2005

Recent research published from the United States has chronicled the enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid (Abeta).

"S-100B is an astrocyte-derived protein that is increased in focal areas of the brain most severely affected by neuropathological changes in Alzheimer disease (AD). Cell-based and clinical studies have implicated S-100B in progression of a pathologic, glial-mediated pro-inflammatory state in the CNS.

"However, the relationship between S-100B levels and susceptibility to AD-relevant neuroinflammation and neuronal...

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Source: Gene Therapy Weekly (2005-09-08)

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