Published in Gene Therapy Weekly, September 15th, 2005
According to recent research from England AND THE United States, "Non-viral gene therapy is being considered as a treatment for cystic fibrosis. In clinical studies and in studies using the mouse airways as a model, current formulations result in only transient transgene expression. A number of reasons for this have been proposed including the loss of plasmid DNA from cells. The aim of these studies was to investigate why transgene expression from non-viral vectors is transient in the mouse lung."
"Plasmid DNA encoding the luciferase reporter gene was...
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