Obliterative Bronchiolitis
Dual role of VEGF in transplant obliterative bronchiolitis revealed
Published in Gene Therapy Weekly, September 15th, 2005
According to R. Krebs and associates at Helsinki University Central Hospital, "OB is the major limitation for long-term survival of lung allograft recipients. We investigated the role of VEGF in the development of OB in rat tracheal allografts. In nonimmunosuppressed allografts, VEGF mRNA and protein expression vanished in the epithelium and increased in smooth muscle cells and mononuclear inflammatory cells with progressive loss of epithelium and airway occlusion compared with syngeneic grafts."
The scientists noted,...
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Source: Gene Therapy Weekly (2005-09-15)
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