Published in Gene Therapy Weekly, September 22nd, 2005
"Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein-protein interactions with various cellular proteins," scientists in Korea reported.
"In order to better understand the mechanism by which merlin exerts its function, yeast two-hybrid screening was performed and RalGDS, a downstream molecule of Ras, was identified as a...
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