Meningioma

Merlin tumor suppressor inhibited Ral guanine nucleotide dissociation stimulator

Published in Gene Therapy Weekly, September 22nd, 2005

The merlin tumor suppressor inhibited Ral guanine nucleotide dissociation stimulator (RalGDS).

"Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein-protein interactions with various cellular proteins," scientists in Korea reported.

"In order to better understand the mechanism by which merlin exerts its function, yeast two-hybrid screening was performed and RalGDS, a downstream molecule of Ras, was identified as a...

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Source: Gene Therapy Weekly (2005-09-22)

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