Published in Gene Therapy Weekly, September 29th, 2005
"The VAChT regulates the amount of acetylcholine stored in synaptic vesicles. However, the mechanisms that control the targeting of VAChT and other synaptic vesicle proteins are still poorly comprehended," wrote L.T. Ferreira and colleagues, Universidade Federal de Minas Gerais.
"These processes are likely to depend, at least partially, on structural determinants present in the primary sequence of the protein. Here, we use site-directed mutagenesis to evaluate the contribution of the C-terminal tail of...
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