Gene Research

VEGF-A gene deletion disrupts thymus blood vessel architecture

Published in Gene Therapy Weekly, September 29th, 2005

VEGF-A gene deletion disrupts thymus blood vessel architecture.

According to a study from Germany, "the thymus harbors an organ-typical dense network of branching and anastomosing blood vessels. To address the molecular basis for morphogenesis of this thymus-specific vascular pattern, we have inactivated a key vascular growth factor, VEGF-A, in thymus epithelial cells (TECs)."

"Both Vegf-A alleles were deleted in TECs by a complementation strategy termed nude mouse [mutated in the transcription factor Foxn1 (forkhead box N1)] blastocyst complementation. Injection of Foxn1+/+ ES cells into Foxn1(nu/nu) blastocysts reconstituted a functional thymus,"...

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Source: Gene Therapy Weekly (2005-09-29)

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