Published in Gene Therapy Weekly, September 29th, 2005
According to recent research from the Netherlands, "in vitro models have been extensively used to map gene expression in endothelial cells (ECs) but few studies have used cells from in vivo sources directly. Here, we compare different gene expression surveys on both cultured and fresh tissue derived ECs, and it emerges that gene expression profiles can be paralleled with the angiogenic stage of the cells."
"ECs stimulated with different growth factors in monolayer cultures exhibit gene expression profiles indicative of an active proliferative state, whereas gene expression in tube...
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