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Gene Therapy

RCVD enhances myocardial plasmid expression

Published in Gene Therapy Weekly, September 29th, 2005

Retrograde coronary venous delivery (RCVD) enhances myocardial plasmid expression.

"Myocardial delivery of genes holds great promise for treating many heart diseases; however, the optimal delivery technique, which maximizes safety and efficacy, has not been established. Two delivery techniques were evaluated in swine; percutaneous retrograde coronary venous delivery (RCVD) and direct intramyocardial injection (IM). RCVD was performed in the anterior interventricular vein (AIV) with an end-hole occlusion balloon catheter," scientists in the United States report.

"The plasmid gWiz, encoding beta-galactosidase (10 ml; 1 mg/mL), was injected using either...

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